PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS
作者： Pablo Rodriguez-Viciana , Patricia H. Warne , Ritu Dhand , Bart Vanhaesebroeck , Ivan Gout
DOI: 10.1038/370527A0
关键词: Proto-Oncogene Proteins p21(ras) 、 GTPase-activating protein 、 SH3 domain 、 Biology 、 COS cells 、 HRAS 、 Anti-apoptotic Ras signalling cascade 、 Growth factor receptor 、 Molecular biology 、 Kinase
摘要: Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through effector site. In vivo, dominant negative mutant N17 inhibits growth factor induced production 3' phosphorylated phosphoinositides PC12 cells, and transfection Ras, but not Raf, into COS cells results large elevation level these lipids. Therefore can probably regulate kinase, providing point divergence signalling pathways downstream Ras.
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