Crosstalk Between Mitogen-Activated Protein Kinase and Phosphoinositide-3 Kinase Signaling Pathways in Development and Disease

摘要: In animals, myriad chemical signals flow between and within cells to maintain life’s balancing act. The “flow” of these signals, or signaling pathways, ultimately dictates how respond changes in their environment, from local tissue injury food scarcity. During embryogenesis, the same pathways function transduce extracellular cues that guide development. Two most ubiquitous evolutionarily conserved cell are mitogen-activated protein kinase (MAPK) phosphoinositide-3 (PI3K) pathways. two involved a wide range critical cellular functions, such as growth differentiation. They also linked together part complex network regulates embryonic development, disruption this can result variety diseases like cancers. Consequently, better mechanistic understanding MAPK PI3K crosstalk them will inform strategies for future therapy. chapter, we discuss role animal development neoplastic transformations, with focus on multiple layers go