Herceptin-induced Inhibition of Phosphatidylinositol-3 Kinase and Akt Is Required for Antibody-mediated Effects on p27, Cyclin D1, and Antitumor Action
作者： Steven Seelig , Carlos L. Arteaga , Walter King , F. Michael Yakes , Wichai Chinratanalab
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摘要: … majority of p27 was present in the cytosol. Myr-Akt eliminated the low basal nuclear levels of p27 but did not alter the basal cytosolic content of p27 (Fig. 7,B). In cells infected with β-gal …
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