The Impact of ErbB2 on Cancer Progression and Metastasis through Modulation of Tumor and Tumor Microenvironment
作者： Valerie Stone Hawthorne , Dihua Yu
DOI: 10.1007/978-1-4020-8341-9_4
关键词: Cancer research 、 JAK-STAT signaling pathway 、 Tumor microenvironment 、 Medicine 、 Angiogenesis 、 Cancer cell 、 Metastasis 、 Oncogene 、 Breast cancer 、 Homing (hematopoietic)
摘要: ErbB2 over-expression in cancer cells leads to a variety of biological consequences. These include cell cycle deregulation, increased invasion, altered adhesion, therapeutic resistance, extra-cellular remodeling, angiogenesis, abnormal stromal-epithelial interactions, disrupted integrin signaling and homing metastasis. Here, we review the current past literature demonstrate how can impact cell-cell, cell-stromal cell-matrix further promoting progression. Through understanding full interactive picture involved ErbB2-mediated progression, new-targeted therapies may bring promise clinic, benefiting patients who have over-expressing cancers.
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