Notch signaling is required for arterial-venous differentiation during embryonic vascular development.
作者： Ajay B. Chitnis , Nico Scheer , Van N. Pham , Jose A. Campos-Ortega , Nathan D. Lawson
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摘要: Recent evidence indicates that acquisition of artery or vein identity during vascular development is governed, in part, by genetic mechanisms. The artery-specific expression a number Notch signaling genes mouse and zebrafish suggests this pathway may play role arterial-venous cell fate determination development. We show loss embryos leads to molecular defects differentiation, including markers ectopic venous within the dorsal aorta. Conversely, we find activation repression fate. Finally, lacking function exhibit blood vessel formation similar those associated with improper specification. Our results suggest required for proper arterial vessels, major vessels repress differentiation developing arteries. Movies available on-line
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