Analysis of signaling protein kinases in human colon or colorectal carcinomas
作者： Laura L. Licato , David A. Brenner
关键词:
摘要: Extracellular signal-related kinase (ERK) and c-Jun N-terminal (JNK) mitogenactivated protein (MAP) kinases are highly activated in an vivo rat model of colorectal carcinogenesis. In addition, other such as c-Src c-Yes have been shown to be up-regulated some human colon cancers. To evaluate the activity these carcinomas, we examined cancers adjacent normal intestinal mucosa from 11 patients. Moderate increases ERK JNK activities, addition up-regulation c-Src, p125FAK, tyrosine-phosphorylated proteins, were observed a subset carcinomas. There was significant correlation found between levels well activity. This is first report that examines several different markers characterize same carcinoma sample, allowing determination correlations tumors.
springer.com
sci-hub.se 参考文章(52)
John K. Westwick, David A. Brenner, [35] Methods for analyzing c-Jun kinase Methods in Enzymology. ,vol. 255, pp. 342- 359 ,(1995) , 10.1016/S0076-6879(95)55037-2
James Chen, Carolyn Compton, Edward Cheng, Frank Fromowitz, Michael V. Viola, c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis Gastroenterology. ,vol. 102, pp. 1983- 1987 ,(1992) , 10.1016/0016-5085(92)90323-Q
S.K. Gupta, C Gallego, G.L. Johnson, L.E. Heasley, MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. Journal of Biological Chemistry. ,vol. 267, pp. 7987- 7990 ,(1992) , 10.1016/S0021-9258(18)42397-6
T Smeal, B Binetruy, D Mercola, A Grover-Bardwick, G Heidecker, U R Rapp, M Karin, Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Molecular and Cellular Biology. ,vol. 12, pp. 3507- 3513 ,(1992) , 10.1128/MCB.12.8.3507
K Kovary, R Bravo, The jun and fos protein families are both required for cell cycle progression in fibroblasts. Molecular and Cellular Biology. ,vol. 11, pp. 4466- 4472 ,(1991) , 10.1128/MCB.11.9.4466
M L Samuels, M J Weber, J M Bishop, M McMahon, Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Molecular and Cellular Biology. ,vol. 13, pp. 6241- 6252 ,(1993) , 10.1128/MCB.13.10.6241
Fumio Imamura, Kiyoko Shinkai, Mutsuko Mukai, Kiyoko Yoshioka, Rika Komagome, Teruo Iwasaki, Hitoshi Akedo, rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion. International Journal of Cancer. ,vol. 65, pp. 627- 632 ,(1996) , 10.1002/(SICI)1097-0215(19960301)65:5<627::AID-IJC12>3.0.CO;2-4
C. A. Cartwright, A. I. Meisler, W. Eckhart, Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 558- 562 ,(1990) , 10.1073/PNAS.87.2.558
J. S. Campbell, M. P. Wenderoth, S. D. Hauschka, E. G. Krebs, Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 870- 874 ,(1995) , 10.1073/PNAS.92.3.870
Susan V. Peña, Mona F. Melhem, Arnold I. Meisler, Christine A. Cartwright, Elevated c-yes tyrosine kinase activity in premalignant lesions of the colon Gastroenterology. ,vol. 108, pp. 117- 124 ,(1995) , 10.1016/0016-5085(95)90015-2