Hypoxia-Directed Drug Strategies to Target the Tumor Microenvironment
作者： Michael P. Hay , Kevin O. Hicks , Jingli Wang
DOI: 10.1007/978-1-4614-5915-6_6
关键词:
摘要: Hypoxia is an important component of the tumor microenvironment and has been target drug discovery efforts for almost half a century. These have evolved from offsetting impact hypoxia on radiotherapy with oxygen-mimetic radiosensitizers to using as means selectively tumors. The more recent description hypoxia-inducible factors their role in response network revealed host new targets We are developing hypoxia-directed drugs each following areas: novel hypofractionated radiotherapy, second-generation benzotriazine di-N-oxide hypoxia-activated prodrug, factor-1–dependent cytotoxin that glucose transport. projects discussed context discovery.
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sci-hub.st 参考文章(287)
Elaine M. Zeman, V.Kate Hirst, Marilyn J. Lemmon, J.Martin Brown, Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233 Radiotherapy and Oncology. ,vol. 12, pp. 209- 218 ,(1988) , 10.1016/0167-8140(88)90263-0
Stephen W. Tuttle, Amit Maity, Patricia R. Oprysko, Alexander V. Kachur, Iraimoudi S. Ayene, John E. Biaglow, Cameron J. Koch, Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration IMPLICATIONS FOR THE MECHANISM OF HIF-1α STABILIZATION UNDER MODERATE HYPOXIA Journal of Biological Chemistry. ,vol. 282, pp. 36790- 36796 ,(2007) , 10.1074/JBC.M700327200
J Overgaard, M Overgaard, A R Timothy, Studies of the pharmacokinetic properties of nimorazole British Journal of Cancer. ,vol. 48, pp. 27- 34 ,(1983) , 10.1038/BJC.1983.153
Sandip Basu, Personalized versus evidence-based medicine with PET-based imaging Nature Reviews Clinical Oncology. ,vol. 7, pp. 665- 668 ,(2010) , 10.1038/NRCLINONC.2010.121
Natsuho Yamamoto, Anna K. Renfrew, Byung J. Kim, Nicole S. Bryce, Trevor W. Hambley, Dual targeting of hypoxic and acidic tumor environments with a cobalt(III) chaperone complex. Journal of Medicinal Chemistry. ,vol. 55, pp. 11013- 11021 ,(2012) , 10.1021/JM3014713
L. J. Dubois, N. G. Lieuwes, M. H. M. Janssen, W. J. M. Peeters, A. D. Windhorst, J. C. Walsh, H. C. Kolb, M. C. Ollers, J. Bussink, G. A. M. S. van Dongen, A. van der Kogel, P. Lambin, Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 14620- 14625 ,(2011) , 10.1073/PNAS.1102526108
Michael P Hay, Kevin O Hicks, Frederik B Pruijn, Karin Pchalek, Bronwyn G Siim, William R Wilson, William A Denny, None, Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport. Journal of Medicinal Chemistry. ,vol. 50, pp. 6392- 6404 ,(2007) , 10.1021/JM070670G
R.P. Hill, Sensitizers and radiation dose fractionation: results and interpretations. International Journal of Radiation Oncology Biology Physics. ,vol. 12, pp. 1049- 1054 ,(1986) , 10.1016/0360-3016(86)90223-3
Alan E. Lee, William R. Wilson, Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicology and Applied Pharmacology. ,vol. 163, pp. 50- 59 ,(2000) , 10.1006/TAAP.1999.8834
Kasper Toustrup, Brita Singers Sørensen, Marianne Nordsmark, Morten Busk, Carsten Wiuf, Jan Alsner, Jens Overgaard, Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer Cancer Research. ,vol. 71, pp. 5923- 5931 ,(2011) , 10.1158/0008-5472.CAN-11-1182