Oxygenation Imaging by Nuclear Magnetic Resonance Methods

摘要: Oxygen monitoring is a topic of exhaustive research due to its central role in many biological processes, from energy metabolism gene regulation. The ability monitor vivo the physiological distribution and dynamics oxygen subcellular macroscopic levels prerequisite better understand mechanisms associated with both normal disease states (cancer, neurodegeneration, stroke, etc.). This chapter focuses on magnetic resonance imaging (MRI) based techniques assess oxygenation vivo. first methodology uses injected fluorinated agents provide quantitative pO2 measurements high precision suitable spatial temporal resolution for applications. second method exploits changes endogenous contrasts, i.e., deoxyhemoglobin molecules through T 2* 1, response an intervention qualitatively evaluate hypoxia potential modulation.