Derek Claxton
机构: Assistant Prof, Vanderbilt University
每年引用次数
引用次数
引用: 1,367
H-指数: 16
I10-指数 : 19
出版物: 33
Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA
Swastik Phulera , Hongtao Zhu , Jie Yu , Derek P Claxton
eLife 7
70
2018
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters
Derek P Claxton , Matthias Quick , Lei Shi , Fernanda Delmondes De Carvalho
Nature Structural & Molecular Biology 17 ( 7) 822 -829
163
2010
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
April Goehring , Chia-Hsueh Lee , Kevin H Wang , Jennifer Carlisle Michel
Nature Protocols 9 ( 11) 2574 -2585
277
2014
Molecular mechanisms of catalytic inhibition for active site mutations in glucose-6-phosphatase catalytic subunit 1 linked to glycogen storage disease
Matt Sinclair , Richard A Stein , Jonathan H Sheehan , Emily M Hawes
bioRxiv 2023 -03
2023
Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model
Matt Sinclair , Richard A Stein , Jonathan H Sheehan , Emily M Hawes
PNAS nexus 3 ( 2) pgae036 -pgae036
1
2024
Cholesterol as an allosteric regulator of hepatic glucose-6-phosphatase
Matt Sinclair , Derek P Claxton , Emad Tajkhorshid
Biophysical Journal 123 ( 3) 482a -482a
2024
Simulations reveal the role of glucose-6-phosphatase mutations in glycogen storage disease
Matt Sinclair , Jonathan Sheehan , Richard A Stein , Derek P Claxton
Biophysical journal 122 ( 3) 185a -185a
2023
Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose
Emily M Overway , Karin J Bosma , Derek P Claxton , James K Oeser
Journal of Biological Chemistry 298 ( 2)
10
2022
Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1
Derek P Claxton , Emily M Overway , James K Oeser , Richard M O'Brien
Journal of Biological Chemistry 298 ( 1)
13
2022
Biochemical and metabolic characterization of a G6PC2 inhibitor
Emily M Hawes , Mohsin Rahim , Zeinab Haratipour , Abigail R Orun
Biochimie 222 109 -122
2024
Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model
Emily M Hawes , Derek P Claxton , James K Oeser , Richard M O’Brien
Bioscience Reports 44 ( 1) BSR20231851 -BSR20231851
2
2024
Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter.
T. Kusakizako , D.P. Claxton , Y. Tanaka , A.D. Maturana
Structure 27 ( 2) 293
11
2019
Structural Studies of a Model Substrate Bound to –Crystallin
H.S. Mchaourab , D. Claxton
Investigative Ophthalmology & Visual Science 47 ( 13) 1519 -1519
2006