Paul Clarke
机构: Institute of Cancer Research
每年引用次数
引用次数
引用: 16,583
H-指数: 56
I10-指数 : 96
出版物: 215
Resisting Targeted Therapy: Fifty Ways to Leave Your EGFR
Paul Workman , Paul A. Clarke
Cancer Cell 19 ( 4) 437 -440
20
2011
Personalized Medicine: Patient-Predictive Panel Power
Paul Workman , Paul A. Clarke , Bissan Al-Lazikani
Cancer Cell 21 ( 4) 455 -458
12
2012
HSF1 in Translation
Emmanuel de Billy , Paul A. Clarke , Paul Workman
Cancer Cell 24 ( 2) 147 -149
7
2013
Translational control by the Epstein-Barr virus small RNA EBER-1. Reversal of the double-stranded RNA-induced inhibition of protein synthesis in reticulocyte lysates.
Paul A. CLARKE , Nigel A. SHARP , Michael J. CLEMENS
FEBS Journal 193 ( 3) 635 -641
116
1990
Mechanism of action of a novel series of inhibitors of the Hsp90 molecular chaperone
Florence Raynaud , Christomos Prodromou , Suzanne Eccles , Kathy Boxall
Cancer Research 64 922 -923
1
2004
Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Mitch Dowsett , Stephen R. D. Johnston , Melanie Valenti , Simone Detre
Clinical Cancer Research 7 ( 11) 3544 -3550
94
2001
Interactions between the double-stranded RNA binding motif and RNA: definition of the binding site for the interferon-induced protein kinase DAI (PKR) on adenovirus VA RNA.
Michael Mathews , Paul A. Clarke
RNA 1 ( 1) 7 -20
75
1995
Targeting the two major isoforms of heat shock protein 70: A novel approach to inhibiting the molecular chaperone heat shock protein 90
Marissa V. Powers , Paul A. Clarke , Paul Wokman
Cancer Research 66 45 -45
2006
Abstract C7: Sensitization of human colorectal cancer cells to TRAIL induced‐apoptosis following inhibition of PI3K or HSP90
Grazia Saturno , Paul A. Clarke , Paul Workman
Molecular Cancer Therapeutics 8
2009
A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer
Charlotte K. Milton , Annette J. Self , Paul A. Clarke , Udai Banerji
Molecular Cancer Therapeutics 19 ( 7) 1423 -1435
1
2020
Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma
Nada M. S. Al-Saffar , Lynley V. Marshall , L. Elizabeth Jackson , Geetha Balarajah
PLoS ONE 9 ( 8) e103835
19
2014
Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis
Marissa V. Powers , Paul A. Clarke , Paul Workman
Cancer Cell 14 ( 3) 250 -262
257
2008
The expanding proteome of the molecular chaperone HSP90
Rahul S. Samant , Paul A. Clarke , Paul Workman
Cell Cycle 11 ( 7) 1301 -1308
22
2012
Discovery of small molecule cancer drugs: Successes, challenges and opportunities
Swen Hoelder , Paul A. Clarke , Paul Workman
Molecular Oncology 6 ( 2) 155 -176
613
2012
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
Georgios Vlachogiannis , Somaieh Hedayat , Alexandra Vatsiou , Yann Jamin
Science 359 ( 6378) 920 -926
495
2018
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells
Nada M. S. Al-Saffar , Alice Agliano , Lynley V. Marshall , L. Elizabeth Jackson
PLOS ONE 12 ( 7) e0180263
2
2017
Blocking the survival of the nastiest by HSP90 inhibition
Paul Workman , Paul A. Clarke , Bissan Al-Lazikani
Oncotarget 7 ( 4) 3658 -3661
10
2016
2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19
Aurélie Mallinger , Kai Schiemann , Christian Rink , Jimmy Sejberg
ACS Medicinal Chemistry Letters 7 ( 6) 573 -578
25
2016
Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer
Paul A. Clarke , Toby Roe , Kate Swabey , Steve M. Hobbs
Oncogene 38 ( 25) 5076 -5090
25
2019
Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases.
Chi Zhang , Simon R. Stockwell , May Elbanna , Robin Ketteler
Oncogene 38 ( 30) 5905 -5920
7
2019