HSF1 in Translation
作者： Emmanuel de Billy , Paul A. Clarke , Paul Workman
DOI: 10.1016/J.CCR.2013.07.017
关键词:
摘要: The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but mechanisms remain poorly understood. A recent study connects increased protein translation to activation HSF1 malignant cells and demonstrates therapeutic benefit targeting this link.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(10)
Onn Brandman, Jacob Stewart-Ornstein, Daisy Wong, Adam Larson, Christopher C. Williams, Gene-Wei Li, Sharleen Zhou, David King, Peter S. Shen, Jimena Weibezahn, Joshua G. Dunn, Silvi Rouskin, Toshifumi Inada, Adam Frost, Jonathan S. Weissman, A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress Cell. ,vol. 151, pp. 1042- 1054 ,(2012) , 10.1016/J.CELL.2012.10.044
Chengkai Dai, Sandro Santagata, Zijian Tang, Jiayuan Shi, Junxia Cao, Hyoungtae Kwon, Roderick T. Bronson, Luke Whitesell, Susan Lindquist, Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis Journal of Clinical Investigation. ,vol. 122, pp. 3742- 3754 ,(2012) , 10.1172/JCI62727
Heather Sadlish, Gabriela Galicia-Vazquez, C. Gregory Paris, Thomas Aust, Bhupinder Bhullar, Lena Chang, Stephen B. Helliwell, Dominic Hoepfner, Britta Knapp, Ralph Riedl, Silvio Roggo, Sven Schuierer, Christian Studer, John A. Porco, Jerry Pelletier, N. Rao Movva, Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. ACS Chemical Biology. ,vol. 8, pp. 1519- 1527 ,(2013) , 10.1021/CB400158T
S. Santagata, M. L. Mendillo, Y.-c. Tang, A. Subramanian, C. C. Perley, S. P. Roche, B. Wong, R. Narayan, H. Kwon, M. Koeva, A. Amon, T. R. Golub, J. A. Porco, L. Whitesell, S. Lindquist, Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. ,vol. 341, pp. 1238303- 1238303 ,(2013) , 10.1126/SCIENCE.1238303
Bissan Al-Lazikani, Udai Banerji, Paul Workman, Combinatorial drug therapy for cancer in the post-genomic era Nature Biotechnology. ,vol. 30, pp. 679- 692 ,(2012) , 10.1038/NBT.2284
Eun-Ho Kim, Yoon-Jin Lee, Sangwoo Bae, Jae Seon Lee, Joon Kim, Yun-Sil Lee, None, Heat Shock Factor 1–Mediated Aneuploidy Requires a Defective Function of p53 Cancer Research. ,vol. 69, pp. 9404- 9412 ,(2009) , 10.1158/0008-5472.CAN-09-1411
Julius Anckar, Lea Sistonen, Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease Annual Review of Biochemistry. ,vol. 80, pp. 1089- 1115 ,(2011) , 10.1146/ANNUREV-BIOCHEM-060809-095203
Marc L. Mendillo, Sandro Santagata, Martina Koeva, George W. Bell, Rong Hu, Rulla M. Tamimi, Ernest Fraenkel, Tan A. Ince, Luke Whitesell, Susan Lindquist, HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers Cell. ,vol. 150, pp. 549- 562 ,(2012) , 10.1016/J.CELL.2012.06.031
Chengkai Dai, Luke Whitesell, Arlin B. Rogers, Susan Lindquist, Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis Cell. ,vol. 130, pp. 1005- 1018 ,(2007) , 10.1016/J.CELL.2007.07.020
Chengkai Dai, Siyuan Dai, Junyue Cao, Proteotoxic stress of cancer: Implication of the heat‐shock response in oncogenesis Journal of Cellular Physiology. ,vol. 227, pp. 2982- 2987 ,(2012) , 10.1002/JCP.24017