The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
Sonia C Dolfi , Leo Li-Ying Chan , Jean Qiu , Philip M Tedeschi
Cancer and Metabolism 1 ( 1) 20 -20
116
2013
Quantification of folate metabolism using transient metabolic flux analysis.
Philip M Tedeschi , Nadine Johnson-Farley , Hongxia Lin , Laura M Shelton
Cancer and Metabolism 3 ( 1) 6 -6
16
2015
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination
Philip M Tedeschi , Yamini K Kathari , Iqra Farooqi , Joseph R Bertino
Cancer Research 74 ( 19_Supplement) 843 -843
2014
NAD+ Kinase inhibition synergizes with ROS-inducing chemotherapies.
Philip M Tedeschi , John Kerrigan , Debabrata Banerjee , Joseph R Bertino
Cancer Research 73 ( 8_Supplement) 5536 -5536
2013
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
K M Hirshfield , L G Boros , J R Bertino , Z N Oltvai
Cell Death and Disease 4 ( 10)
255
2013
Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development
Philip M. Tedeschi , Alexei Vazquez , John E. Kerrigan , Joseph R. Bertino
Molecular Cancer Research 13 ( 10) 1361 -1366
42
2015
Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors
Alexei Vazquez , Philip M. Tedeschi , Joseph R. Bertino
Cancer Research 73 ( 2) 478 -482
52
2013
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts
Philip M. Tedeschi , Yamini K. Kathari , Iqra N. Farooqi , Joseph R. Bertino
Cancer Chemotherapy and Pharmacology 74 ( 5) 1029 -1032
15
2014
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.
Philip M. Tedeschi , Yamini K. Kathari , Nadine Johnson-Farley , Joseph R. Bertino
Cancer Chemotherapy and Pharmacology 75 ( 6) 1247 -1252
1
2015
Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy
Philip M. Tedeschi , HongXia Lin , Murugesan Gounder , John E. Kerrigan
Molecular Pharmacology 88 ( 4) 720 -727
15
2015
NAD+ Kinase as a Therapeutic Target in Cancer
Philip M. Tedeschi , Nitu Bansal , John E. Kerrigan , Emine E. Abali
Clinical Cancer Research 22 ( 21) 5189 -5195
32
2016
MTHFD2- a new twist?
Philip M. Tedeschi , Kathleen W. Scotto , John Kerrigan , Joseph R. Bertino
Oncotarget 7 ( 7) 7368 -7369
8
2016
Abstract A266: Leucovorin rescue of high dose pralatrexate in mesothelioma xenografts.
Philip M. Tedeschi , Iqra Farooqi , Yamini Kathari , Joseph R. Bertino
Molecular Cancer Therapeutics 12
2013
Abstract C151: Contribution of serine, folate, and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells.
Philip M. Tedeschi , Elke K. Markert , Murugesan Gounder , HongXia Lin
Molecular Cancer Therapeutics 12
2013
Functional annotation of rare gene aberration drivers of pancreatic cancer
Armel Dogruluk , Min Li , Haoqiang Ying , Joseph R. Bertino
Nature Communications 7 ( 1) 10500 -10500
60
2016
Cell proliferation and tissue remodeling are major determinants of cancer metabolism and the response to drugs targeting metabolism
Elke Markert , Philip Tedeschi , Sonia Dolphi , Kim Hirshfield
Cancer and Metabolism 2 ( 1) 80
2014
Abstract PR06: Functional prioritization of rare gene aberration drivers of cancer
Kenneth Scott , Yiu Huen Tsang , Turgut Dogruluk , Philip Tedeschi
Cancer Research 75
2015
Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs.
Yi-Ching Hsieh , Philip Tedeschi , Rialnat AdeBisi Lawal , Debabrata Banerjee
Molecular Pharmacology 83 ( 2) 339 -353
19
2013
The castrate resistant PC-3 cell line with neuroendocrine features is enriched in tumor initiating cells and is resistant to enzalutamide and abiraterone but sensitive to antimetabolites
Nitu Bansal , Lisa Wu , Nadine Johnson Farley , Philip Tedeschi
Cancer Research 75 ( 15_Supplement) 4208 -4208
2
2015
In cancer, all roads lead to NADPH
Philip Michael Tedeschi , Alvinsyah Adhityo Pramono , Zoltan Szekely , Gulam Mohmad Rather
Pharmacology & Therapeutics 226 107864 -107864
2021