B.E. Pagarigan
机构: Principal Scientist - Bristol Myers Squibb
每年引用次数
引用次数
引用: 1,912
H-指数: 11
I10-指数 : 11
出版物: 16
Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes
Philip Chamberlain , Silvia Delker , Barbra Pagarigan , Afshin Mahmoudi
PLoS ONE 9 ( 8) e103638
10
2014
Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex
Mary E. Matyskiela , Thomas Clayton , Xinde Zheng , Christopher Mayne
Nature Structural & Molecular Biology 27 ( 4) 319 -322
13
2020
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
Jennifer R. Riggs , Jan Elsner , Dan Cashion , Dale Robinson
Journal of Medicinal Chemistry 62 ( 9) 4401 -4410
10
2019
Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
Mary Matyskiela , Gang Lu , Takumi Ito , Barbra Pagarigan
Cancer Research 77
2017
Inhibitor Binding Mode Differences Within the AGC Subfamily
Silvia Delker , Dale Robinson , Sami Bahmanyar , Barbra Pagarigan
Acta Crystallographica Section A 70
2014
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Philip P Chamberlain , Antonia Lopez-Girona , Karen Miller , Gilles Carmel
Nature Structural & Molecular Biology 21 ( 9) 803 -809
442
2014
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen
Jennifer R. Riggs , Mark Nagy , Jan Elsner , Paul Erdman
Journal of Medicinal Chemistry 60 ( 21) 8989 -9002
20
2017
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation
Gregory D. Ferguson , Mercedes Delgado , Veronique Plantevin-Krenitsky , Kristen Jensen-Pergakes
PLOS ONE 11 ( 1) e0145705
5
2016
A novel cereblon modulator recruits GSPT1 to the CRL4 CRBN ubiquitin ligase
Mary E. Matyskiela , Gang Lu , Takumi Ito , Barbra Pagarigan
Nature 535 ( 7611) 252 -257
395
2016
Structure of the human marker of self 5-transmembrane receptor CD47
Gustavo Fenalti , Nicolas Villanueva , Mark Griffith , Barbra Pagarigan
Nature communications 12 ( 1) 5218
11
2021
The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima
Frances Park , Ketan Gajiwala , Brian Noland , Lydia Wu
Proteins 55 ( 3) 772 -774
23
2004
A cereblon modulator (CC-220) with improved degradation of Ikaros and Aiolos
Mary E Matyskiela , Weihong Zhang , Hon-Wah Man , George Muller
Journal of medicinal chemistry 61 ( 2) 535 -542
274
2018
MiRNAs appear to target about 60% of the genes of humans and other mammals.
Mary E Matyskiela , Weihong Zhang , Hon-Wah Man , George Muller
eIF4E mRNA-cap-competitive covalent inhibitors: Design, synthesis and effectiveness
Virginia Grant , Deborah Mortensen , Lisa Nadolny , Stephen Norris
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258
2019
Potent [1, 2, 4] triazolo [1, 5-a] pyridine and 1H-pyrazolo [3, 4-d] pyrimidine inhibitors of polo-like kinase 1 and the structural basis for divergent SAR between the series
Philip Chamberlain , Sogole Sami Bahmanyar , Barbra Pagarigan , Palka Patel
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248
2014
Structural analysis of a set of proteins resulting from a bacterial genomics project.
J. Badger , J.M. Sauder , J.M. Adams , S. Antonysamy
Proteins 60 ( 4) 787 -796
208
2005