A novel cereblon modulator recruits GSPT1 to the CRL4 CRBN ubiquitin ligase

作者: Mary E. Matyskiela , Gang Lu , Takumi Ito , Barbra Pagarigan , Chin-Chun Lu

DOI: 10.1038/NATURE18611

关键词: DNA-binding proteinUbiquitinDegronDNA ligaseCereblonCell biologyUbiquitin ligaseUbiquitin-Protein LigasesChemistryPlasma protein binding

摘要: … of sequence homology with human GSPT1, but did not … of GSPT1 glycine 575 into the corresponding asparagine of SUP35 prevented both the CC-885-induced degradation of GSPT1 …

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