Apoptosis and survival in high-grade astrocytomas as related to tumor Fas (APO-1/CD95) expression.
作者： Bruce Frankel , Sharon L. Longo , Christopher Leach , Gregory W. Canute , Timothy C. Ryken
关键词: Fas receptor 、 Anaplastic astrocytoma 、 Receptor 、 Cancer research 、 Ki-67 、 Immunohistochemistry 、 Apoptosis 、 Fas ligand 、 Gene expression 、 Pathology 、 Medicine
摘要: Although a majority of high-grade gliomas express the apoptosis-inducing receptor Fas, little is known about extent apoptosis or prognostic significance Fas expression in these tumors. In situ labeling apoptotic cells and Ki-67 immunohistochemistry were performed on 51 human astrocytomas previously characterized for expression. Survival data was compiled from patient records correlated with tumor grade, index (AI) A significant correlation found between grade AI (LI); however, only increased significantly The 0.39 ± 0.12% to 0.82 0.10% III vs. IV (P = 0.003). Ki-67-LI 3.64 1.5% 11.35 2.1% 0.004). Additionally, tumors expressing higher levels had greater than those lower (0.81 0.11% 0.43 0.11%) 0.017). Despite longer median survivals patients exhibiting high expression, statistical not achieved. Patients demonstrated survival 20 18 months low 0.51). 9 7.4 respectively 0.77). degree appears correlate rate, no overall differences could be levels.
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