Understanding the burden of human papillomavirus-associated anal cancers in the US

摘要: BACKGROUND. Anal cancer is an uncommon malignancy in the US; up to 93% of anal cancers are associated with human papillomavirus. METHODS. Cases diagnosed between 1998 and 2003 from 39 population-based registries were analyzed. The following histologies included analysis: squamous cell, adenocarcinoma, small cell/neuroendocrine carcinomas. Incidence rates age-adjusted 2000 US standard population. RESULTS. From through 2003, annual invasive incidence rate was 1.5 per 100,000 persons. Squamous cell carcinoma (SCC) most common histology overall, accounting for 18,105 21,395 (84.6%) cases cancer. Women had a higher SCC (1.5 100,000) than men (1.0). Whites blacks highest (1.3), whereas Asians/Pacific Islanders (API) lowest (0.3). increased 2.6% year on average. majority at situ or localized stage (58.1%). API more likely be regional distant disease other racial/ethnic groups (27.5% 11.8%, respectively). Males lower 5-year relative survival females all stages disease. CONCLUSIONS. Rates varied by sex, race, ethnicity. A proportion regional/distant stage. Men women. Continued surveillance additional research needed assess potential impact HPV vaccine burden US. Cancer 2008;113(10 suppl):2892–900. Published 2008 American Society.