Risk factors for anal cancer: results of a population-based case–control study

作者: Hung-Fu Tseng , Hal Morgenstern , Thomas M. Mack , Ruth K. Peters

DOI: 10.1023/B:CACO.0000003837.10664.7F

关键词: EtiologyEpidemiologyMedicineAnal cancerGynecologyObstetricsCase-control studySyphilisHemorrhoidsIncidence (epidemiology)Odds ratioCancer researchOncology

摘要: Objective: Although the incidence of anal cancer is higher in women than men, reasons for this gender difference are not clear. The purpose study was to identify risk factors both men and women. Methods: We conducted in-person interviews with 102 males 106 females squamous or transitional cell carcinoma anus 208 individually matched controls. Results: Compared persons who had never experienced receptive intercourse, those it more 130 times were 18 as likely develop (adjusted odds ratio [OR] = 17.6 (95% confidence interval [CI] 1.3–234). This elevated occurred primarily among males. adjusted OR having 10% their sexual experiences other 5.6 CI 1.4–22.0). A history anogenital endometrial cancers increased but men. warts, syphilis, severe hemorrhoids, physical inactivity, multiple partners smoked, current smoking also associated risk. Conclusions: results suggest that non-sexual important etiology cancer.

参考文章(23)
N. E. Breslow, N. E. Day, Statistical methods in cancer research. Vol. 1. The analysis of case-control studies. International Agency for Research on Cancer Scientific Publications. ,vol. 1, ,(1980)
Frederick Holmes, Deborah Borek, Medge Owen-Kummer, Ruth Hassanein, James Fishback, Abbas Behbehani, Ariel Baker, Grace Holmes, Anal cancer in women Gastroenterology. ,vol. 95, pp. 107- 111 ,(1988) , 10.1016/0016-5085(88)90297-1
LAURIE BAIN, ROY GERONEMUS, The association of lichen planus of the penis with squamous cell carcinoma in situ and with verrucous squamous carcinoma. The Journal of Dermatologic Surgery and Oncology. ,vol. 15, pp. 413- 417 ,(1989) , 10.1111/J.1524-4725.1989.TB03247.X
M Frisch, M Melbye, H Moller, Trends in incidence of anal cancer in Denmark. BMJ. ,vol. 306, pp. 419- 422 ,(1993) , 10.1136/BMJ.306.6875.419
Janet R. Daling, Correlates of Homosexual Behavior and the Incidence of Anal Cancer JAMA: The Journal of the American Medical Association. ,vol. 247, pp. 1988- 1990 ,(1982) , 10.1001/JAMA.1982.03320390050042
Cathy W. Critchlow, Christina M. Surawicz, King K. Holmes, Jane Kuypers, Janet R. Daling, Stephen E. Hawes, Gary M. Goldbaum, James Sayer, Carla Hurt, Carol Dunphy, Nancy B. Kiviat, Prospective study of high grade anal squamous intraepithelial neoplasia in a cohort of homosexual men: influence of HIV infection, immunosuppression, and human papillomavirus infection AIDS. ,vol. 9, pp. 1255- 1262 ,(1995) , 10.1097/00002030-199511000-00007
Morten Frisch, Bengt Glimelius, Adriaan J.C. van den Brule, Jan Wohlfahrt, Chris J.L.M. Meijer, Jan M.M. Walboomers, Sven Goldman, Christer Svensson, Hans-Olov Adami, Mads Melbye, Sexually Transmitted Infection as a Cause of Anal Cancer The New England Journal of Medicine. ,vol. 337, pp. 1350- 1358 ,(1997) , 10.1056/NEJM199711063371904
D. M. Preston, E. Fiona Fowler, J. E. Lennard-Jones, P. R. Hawley, Carcinoma of the anus in Crohn's disease British Journal of Surgery. ,vol. 70, pp. 346- 347 ,(2005) , 10.1002/BJS.1800700612
Xiao-Wei Sun, Louise Kuhn, Tedd V. Ellerbrock, Mary Ann Chiasson, Timothy J. Bush, Thomas C. Wright, Human Papillomavirus Infection in Women Infected with the Human Immunodeficiency Virus The New England Journal of Medicine. ,vol. 337, pp. 1343- 1349 ,(1997) , 10.1056/NEJM199711063371903
Frederick H. Sillman, Rachel G. Fruchter, Yan-Shiun Chen, Louis Camilien, Alexander Sedlis, Ellen McTigue, Vaginal intraepithelial neoplasia: Risk factors for persistence, recurrence, and invasion and its management American Journal of Obstetrics and Gynecology. ,vol. 176, pp. 93- 99 ,(1997) , 10.1016/S0002-9378(97)80018-X