Interleukin-10 compositions for the treatment of adenocarcinomas

作者: Bruce Horwitz , Anne Davidson , James Fox , Susan Erdman

DOI:

关键词: Cancer researchOncogeneInterleukin 10AdenocarcinomaChemistryPathology

摘要: The present invention is directed to methods for the treatment of adenocarcinoma that are characterized by overexpression a particular oncogene, Pim-1. procedur involves administering therapeutically effective amount interleukin-10 has bee coupled carrier increases its circulating plasma half-life.

参考文章(29)
F. Powrie, Regulating the Regulators Science. ,vol. 299, pp. 1030- 1031 ,(2003) , 10.1126/SCIENCE.1082031
Terry B. Strom, Alan Steele, Xin-Xiao Zheng, Chimeric cytokines and uses thereof ,(1995)
T B Strom, P W Nickerson, A W Steele, W Steurer, X X Zheng, J Steiger, Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation Journal of Immunology. ,vol. 154, pp. 5590- 5600 ,(1995)
Terry B. Strom, Alan Steele, Xin Xiao Zheng, Treatment regimes featuring an IL-10-containing chimeric polypeptide ,(1997)
T. B. Strom, P. W. Nickerson, W. W. Hancock, P. Roy-Chaudhury, A. W. Steele, Xin Xiao Zheng, Y. Tian, A. C. Stevens, A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. Journal of Immunology. ,vol. 158, pp. 4507- 4513 ,(1997)
M. J. Stadecker, P. O. Flores-Villanueva, Xin Xiao Zheng, T. B. Strom, Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. Journal of Immunology. ,vol. 156, pp. 3315- 3320 ,(1996)
Terry B. Strom, Alan Steele, Xin Xiao Zheng, Chimeric IL-10 proteins and uses thereof ,(1994)
Susan E. Erdman, Theofilos Poutahidis, Michal Tomczak, Arlin B. Rogers, Kathleen Cormier, Benjamin Plank, Bruce H. Horwitz, James G. Fox, CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice American Journal of Pathology. ,vol. 162, pp. 691- 702 ,(2003) , 10.1016/S0002-9440(10)63863-1