High-resolution solid state 13C nuclear magnetic resonance spectra of 3,4-methylenedioxyamphetamine hydrochloride and related compounds and their mixtures with lactose

摘要: Differences between solution and solid state 13C nuclear magnetic resonance spectra of some amphetamines namely, 3,4-methylenedioxyamphetamine·HCl, (R,S)-MDA·HCl, the methyl derivative 3,4-methylenedioxy-N-methylamphetamine·HCl, (R,S)-MDMA·HCl, ethyl derivative, (R,S)-MDEA·HCl, analogues (R,S)-methamphetamine·HCl, (−)-ephedrine·HCl (the 3R,2S enantiomer as numbered here), (+)-pseudo-ephedrine·HCl 3S,2S here) have been studied related to their crystal structure. For an interesting new finding is that observed chemical shifts changed when lactose monohydrate was added a dry powder thoroughly mixed at room temperature. This experiment mimicked illicit production “Ecstasy” tablets. The mixing phenomena with for (R,S)-MDMA·HCl not seen other compounds studied. results are discussed in terms hydrogen bonding possible polymorphs. It appears affects packing by reducing conformational rigidity so molecule more closely resembles solution.