Role of p53 and apoptosis in carcinogenesis.

摘要: A. Abstract. Carcinogenesis is a process that converts normal cells from controllable to uncontrollable growth. Coordinate regulation of the rates cell proliferation and death an important determinant in maintenance homeostasis. Loss control this balance central development cancer. This loss may be due genetic alteration either growth promoting genes resulting constitutive activation or negative regulating such as tumor suppressor genes. Recent advances studying molecular mechanisms related etiology cancer have provided further understanding these pathways. Earlier studies been primarily concerned with oncogenes. However, many recent focused on induction death. The recognition importance apoptosis, distinct mode death, genomic stability was prompted by mechanism gene product p53, well other oncogenes For example, appear act potent inducers apoptosis through p53 dependent pathways, Therefore, one possible for suppression involves pathways at risk neoplastic transformation. These extensive knowledge signal transduction response genotoxic stress promoted mechanistic research also provide perfect explanation key element maintaining function common event during carcinogenesis. chapter will mainly focus role In particular, I summarize its process.