p53-Dependent anticancer effects of leptomycin B on lung adenocarcinoma.
作者： Changxia Shao , Chuanwen Lu , Lixia Chen , Patrick P. Koty , Everardo Cobos
DOI: 10.1007/S00280-010-1434-6
关键词:
摘要: Purpose Leptomycin B (LMB) and/or its derivatives are considered a novel class of cancer therapeutics through blocking chromosome maintenance region 1, which mediates p53 nuclear export. The objectives the present study were to first evaluate cytotoxic effects LMB on normal human lung epithelial cell line (BEAS-2B) and three adenocarcinoma lines with various status (wild type: A549, mutant: NCI-H522, null: NCI-H358) then identify LMB-induced gene expression alterations in signaling pathway.
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