摘要: The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting mammalian target rapamycin complex 1 (mTORC1). Recent results Budanov and Karin, (2008) reveal that exerts its effect on mTORC1 through sestrin1 sestrin2.
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