Delayed ageing through damage protection by the Arf/p53 pathway
作者： Ander Matheu , Antonio Maraver , Peter Klatt , Ignacio Flores , Isabel Garcia-Cao
DOI: 10.1038/NATURE05949
关键词: Tumor suppressor gene 、 Cell biology 、 Oxidative stress 、 Ageing 、 Biology 、 Cell signaling 、 Transcriptome 、 Cell cycle 、 Signal transduction 、 CDKN2A
摘要: … by Arf and, for simplicity, we will refer to these mice as s-Arf. These single-copy transgenes, s-p53 and s-Arf, are … It is well established that Arf stabilizes p53 and, on the basis of this, we …
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