Lessons on p53 from Mouse Models

摘要: Mutations in the p53 gene are implicated development of at least half all human cancers, a wide variety types.1,2 This high incidence mutations suggests that there exists strong selection pressure for inactivation during tumorigenesis. The idea important tumor humans has also been supported by finding Li-Fraumeni syndrome, individuals inherit mutant allele and show predisposition to developing cancers.3 An unambiguous cause effect relationship, however, between mutation tumorigenesis clearly provided through generation analysis knockout mice.4–6 null mice subject 100% frequency, indicating presence is crucial preventing cancer development. In addition this initial observation, significant understanding role as suppressor come further mouse well other versions with altered genes. chapter, we will summarize various knock-in models how these have helped us understand function vivo.