Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
作者： Jos Jonkers , Ralph Meuwissen , Hanneke van der Gulden , Hans Peterse , Martin van der Valk
DOI: 10.1038/NG747
关键词: Wild type 、 Breast cancer 、 Allele 、 Transgene 、 Suppressor 、 Biology 、 Loss of heterozygosity 、 Cancer research 、 Epithelium 、 Immunology 、 Mammary gland
摘要: … tumor-suppressor function of BRCA2, either alone or in combination with p53 loss, in several epithelial tissues including mammary-gland epithelium. We generated Brca2 F11 mice in …
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