Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome.

摘要: Breast cancer is the most frequent tumor type among women in United States and individuals with Li-Fraumeni syndrome. The p53 suppressor gene altered a large proportion of both spontaneous breast malignancies cancers. This suggests that loss can accelerate tumorigenesis, yet -deficient mice rarely develop mammary tumors. To evaluate effect on formation, null allele was back-crossed onto BALB/c genetic background. Median survival 15.4 weeks for BALB/c- −/− compared to 54 +/− mice. Sarcomas lymphomas were types mice, whereas 55. female developed carcinomas. tumors highly aneuploid, frequently lost remaining wild-type allele, but BRCA1 . Although detected when glands from transplanted into hosts, 75% high rate development background, not C57Bl/6 or 129/Sv, predisposition toward tumorigenesis. Therefore, provide unique model study These results demonstrate critical role plays preventing tumorigenesis gland.