Embryonic Stem Cells: Prospects of Regenerative Medicine for the Treatment of Human Aging

摘要: The human somatic/germ-line dichotomy is characterized by somatic cell lineages displaying a finite replicative capacity and germ-line cells that possess the potential for immortality. in vitro culture of has demonstrated absence genotoxic stress, senescence due to repression telomerase activity resulting progressive shortening telomeres. A growing body data supports role telomeric DNA damage not merely vitro, but age-related disease premature aging syndromes such as Werner syndrome. unique properties cultured embryonic stem (hES) cells, their immortality through high level expression, makes these an attractive source manufacture young types all types. emerging technologies allowing reprogramming patient’s back state resetting telomere length enabled field regenerative medicine, focused on discovering primitive useful repairing tissues afflicted with degenerative disease. While principle, could be manufactured from hES some appear easiest scale, purify, engraft adult tissues, are therefore likely first developed viable products treatment