WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2ΔB-Mediated Telomere Shortening
作者： Baomin Li , Sonali P. Jog , Sita Reddy , Lucio Comai
DOI: 10.1128/MCB.01364-07
关键词: Genome instability 、 Helicase 、 Biology 、 Werner Syndrome Helicase 、 Telomere Homeostasis 、 DNA replication 、 Telomere 、 Cell aging 、 Molecular biology 、 Homologous recombination
摘要: … Interestingly, although overexpression of Flag-TRF2 ΔB in WS cells complemented with WRN lacking either exonuclease or helicase activity did not increase cell senescence, we …
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