Opioid-induced constipation negatively impacts pain management, productivity, and health-related quality of life: findings from the National Health and Wellness Survey.

摘要: Objective: To characterize the impact of opioidinduced constipation (OIC) on healthcare resource use, work productivity, and health-related quality life (HRQOL) in patients receiving chronic opioid therapy. Design: Data were collected via Internet questionnaires during international National Health Wellness Survey (NHWS) 2004 from individuals aged ≥18 years who reported taking opioids for ≥6 months. Healthcare utilization, Work Productivity, Activity Impairment, Short-Form 8 (SF-8) questionnaire responses compared between those did or not report OIC. Results: available 2,430 opioids, whom 359 Participants with OIC significantly more physician visits (mean difference 3.84 visits; p < 0.05) alternative care provider 1.73 over previous 6 months than without OIC; however, no significant differences emergency room number days hospitalization observed. Respondents also greater time missed work, impairment while working, overall impairment, activity (p 0.05 all comparisons). HRQOL scores lower group both physical mental components SF-8 Conclusions: The survey results reflect a negative individuals’ society terms use productivity beyond that imposed by patients’ pain conditions. These findings indicate need effective treatment opioid-induced