Pain therapy with oxycodone/naloxone prolonged-release combination: case report
作者： Feliks Błaszczyk , Aleksandra Droń
关键词:
摘要: Pain afflicts patients suffering from many chronic diseases and is present in 80% of cases with advanced cancer who suffer persistent pain. The aim the pain treatment to achieve maximum analgesic effect while minimizing side effects. main agent – morphine unfortunately a therapy associated gastrointestinal It appears that combination oxycodone naloxone available as Targin® (Mundipharma) an alternative. paper presents case 45-year-old patient was treated effectively oxycodone/naloxone prolonged-release tablets. This has proven be effective providing constipation control.
sci-hub.se 参考文章(21)
Youn Seon Choi, J.Andrew Billings, Opioid antagonists: a review of their role in palliative care, focusing on use in opioid-related constipation. Journal of Pain and Symptom Management. ,vol. 24, pp. 71- 90 ,(2002) , 10.1016/S0885-3924(02)00424-4
Timothy Bell, MHA, Kathy Annunziata, MA, John B. Leslie, MD, MBA, Opioid-induced constipation negatively impacts pain management, productivity, and health-related quality of life: findings from the National Health and Wellness Survey. Journal of opioid management. ,vol. 5, pp. 137- 144 ,(2018) , 10.5055/JOM.2009.0014
S. F. COOK, L. LANZA, X. ZHOU, C. T. SWEENEY, D. GOSS, K. HOLLIS, A. W. MANGEL, S. E. FEHNEL, Gastrointestinal side effects in chronic opioid users: results from a population-based survey Alimentary Pharmacology & Therapeutics. ,vol. 27, pp. 1224- 1232 ,(2008) , 10.1111/J.1365-2036.2008.03689.X
T F Burks, J J Galligan, Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. Journal of Pharmacology and Experimental Therapeutics. ,vol. 226, pp. 356- 361 ,(1983)
Marie T. Fallon, Constipation in cancer patients: Prevalence, pathogenesis, and cost‐related issues European Journal of Pain. ,vol. 3, pp. 3- 7 ,(1999) , 10.1016/S1090-3801(99)90169-6
Peter Holzer, Opioid receptors in the gastrointestinal tract. Regulatory Peptides. ,vol. 155, pp. 11- 17 ,(2009) , 10.1016/J.REGPEP.2009.03.012
Eija Kalso, Anneli Vainio, Morphine and oxycodone hydrochloride in the management of cancer pain Clinical Pharmacology & Therapeutics. ,vol. 47, pp. 639- 646 ,(1990) , 10.1038/CLPT.1990.85
Leland Gershell, J. Jeffrey Goater, Making gains in pain Nature Reviews Drug Discovery. ,vol. 5, pp. 889- 890 ,(2006) , 10.1038/NRD2179
Timothy J. Bell, Sunil J. Panchal, Christine Miaskowski, Susan C. Bolge, Tsveta Milanova, Russell Williamson, The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1) Pain Medicine. ,vol. 10, pp. 35- 42 ,(2009) , 10.1111/J.1526-4637.2008.00495.X
Tarja Heiskanen, Eija Kalso, Controlled-release oxycodone and morphine in cancer related pain Pain. ,vol. 73, pp. 37- 45 ,(1997) , 10.1016/S0304-3959(97)00072-9