Gastrointestinal side effects in chronic opioid users: results from a population-based survey

摘要: Summary Background  Gastrointestinal side effects are commonly associated with opioid treatment for pain. Aim  To understand gastrointestinal treatment. Methods  This study was a population-based survey of adults in the US who use opioids to manage pain unrelated cancer. Participants were recruited from an existing Web-enabled panel and supplemental individuals previously indicated interest participating Web-based surveys. Results  Overall, 2055 participated main phase survey. Fifty-seven per cent participants reported having had constipation that they treatment, 49% previous 4 weeks. Thirty-six new or worsening Thirty-three as their most bothersome symptom 13% nausea, 11% abdominal 10% gas. Seventy-three any GI symptoms did not change dosage level frequency because adverse events, which may be explained by fact 72% used over-the-counter laxatives 12% prescription laxative. Conclusion  Constipation is frequent significant event occurring use.