The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia.

摘要: Purpose: To further our understanding of the biology and prognostic significance various chromosomal 13q14 deletions in chronic lymphocytic leukemia (CLL). Experimental Design: We analyzed data from SNP 6.0 arrays to define anatomy a cohort 255 CLL patients have correlated two subsets (type I exclusive RB1 type II inclusive ) with patient survival. Furthermore, we measured expression 13q14-resident microRNAs by quantitative PCR (Q-PCR) 242 subsequently assessed their significance. sequenced all coding exons monoallelic deletion miR locus patients. Results: Large II) were detected approximately 20% associated shortened A strong association between elevated genomic complexity, as through CLL-FISH or array profiling, was identified, suggesting that these lesions may contribute disease evolution destabilization. Sequence copy number analysis gene identified small subset is null. Finally, neither levels nor degree deletion, array-based analysis, had significant importance. Conclusions: Our suggest clinical course accelerated large span gene, therefore justifying routine identification subtypes management. Clin Cancer Res; 17(21); 6778–90. ©2011 AACR .