CHAPTER 75 – Negative Regulation of the JAK/STAT Signaling Pathway

摘要: The JAK/STAT pathway activated by cytokines is also tempered to control both the duration and intensity of signaling. There are various levels at which negative regulation can occur, including downregulation receptor-ligandcomplex, dephosphorylation or degradation signaling intermediates, production and/or activation specific suppressor proteins. This chapter focuses on three classes proteins: phosphatases, protein inhibitors STATs (PIAS), suppressors cytokine These proteins act in fundamentally different ways. Phosphatases PIAS present constitutively capable inhibiting an acute manner. might be expected as buffers determine magnitude initial response. In contrast, SOCS are, general, produced a consequence signal transduction, some hours after cells exposed cytokines. therefore appear regulate perhaps steady-state level signaling, rather than Despite progress understanding how these individual components function, little currently known they concert transduction response chronic stimulation.