Effect of ozone exposure and infection on bronchoalveolar lavage: sex differences in response patterns.

摘要: Abstract Female mice exhibit a better survival rate than males after infection, but if infection follows an ozone-induced oxidative stress, male exceeds that of females. Our goal was to study bronchoalveolar lavage factors contribute these sex differences in outcome. We studied parameters at 4, 24, and 48 h ozone exposure including markers inflammation, tissue damage, surfactant phospholipids protein A (SP-A). multianalyte immunoassay the 4 h time point measured 59 different cytokines, chemokines, other proteins. found that: (1) Although some revealed differences, no were observed LDH, total protein, MIP-2, SP-A. Males showed more intragroup significant SP-A between filtered air- ozone-exposed compared (2) Oxidized dimeric higher FA-exposed female mice. (3) Surfactant typically males. (4) The data exuberance responses under conditions – response females stress. These exuberant, presumably less well-controlled associate with poorer survival. postulate collective effects patterns lung immune cells may clinical outcomes previously observed.