Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions.

摘要: It has been shown that female mice with pneumonia have a survival advantage over males, but this is reversed if ozone exposure precedes infection. The purpose of study was to investigate factors underlie these observations, by studying histopathologic changes in lung and extrapulmonary (spleen liver) tissues after or filtered air (FA) followed pulmonary bacterial Male wild type C57BL/6J were exposed FA, then anesthetized infected intratracheally Klebsiella pneumoniae bacteria. Tissues (lung, spleen, subjected analysis at 48 h post-infection. We found infection, 1) the severity inflammation higher, affected area larger, spleen red pulp myelopoiesis lower ozone-exposed compared FA-exposed animals both sexes; 2) more pronounced lesions (in liver spleen) observed males females; 3) excessive inflammatory response detected females males. concluded different risk contribute differential outcome between sexes presence absence ozone-induced oxidative stress. In specific, higher for appear play, respectively, dominant role previously respective outcomes.