Impact of certain immunomodulators on LPS-induced hematotoxicity

摘要: The present study aimed to explore the extent which immunomodulators may protect against Klebsiella pneumonia lipopolysaccharide (K pn LPS) toxicity. Two (levamisole and DDB) were utilized in work. was carried out on male Sprague Dawley rats, animals divided into four groups: One group injected with saline intraperitoneally (i.p.) served as a control group. other three groups subcutaneously daily repetitive doses of K LPS (10, 10, 20, 20 40 µg/kg, i.p., for 5 consecutive days). these LPS-injected co-treated either levamisole (3 mg/kg, days, p.o) or DDB (6 mg/kg, p.o). At end experiment, effects given treatment evaluated regarding relative spleen thymus weights, certain hematological changes (total differential white blood cells count (WBCs), red (RBCs), platelet (PLAT), hemoglobin content (Hb), bone marrow cell count, well histopathological each spleen, marrow. obtained results revealed that induced body weight loss, splenomegaly, thymic atrophy, leukopenia lymphocytopenia. Each reticulocytes eosinophil percentages noticeably decreased after 5 days administration. drugs potentiated LPS-induced lymphocytopenia increased segmented cells. However, co-administration prior injection could prevent drop nucleated total WBCs, eosinophils restoring them their normal ranges. examination thymus, rats treated two confirmed above-mentioned results. Finally, reveals exerts more pronounced modulatory effect hematotoxicity.