Differential myelopoietic responsiveness of BALB/c (Itys) and C.D2 (Ityr) mice to lipopolysaccharide administration and Salmonella typhimurium infection.

摘要: Inheritance of the Ityr or Itys allele Ity murine gene confers resistance increased susceptibility, respectively, to Salmonella typhimurium infection. Recent studies have documented that expression may determine net intracellular replication S. by modulating macrophage function. The purpose this study was if modulated stem cell proliferation as well. To detect possible Ity-associated alterations in during endotoxin challenge infection, congenic strain pair BALB/c (Itys) and C.D2-Idh-1, Pep-3 N20F8 (Ityr) were injected intraperitoneally with 25 micrograms bacterial lipopolysaccharide (LPS) approximately 10(3) typhimurium, myelopoiesis evaluated. At 72 h after LPS injection, both C.D2 mice developed comparable degrees bone marrow hypocellularity splenomegaly, sizing profiles indicated a normal response single injection strains mice. Although an inhibitor colony-stimulating factor activity detected sera plasma mice, number myeloid cells cultured from spleen each mouse comparable. infection resulted earlier symptoms, larger load, higher mortality rate, greater splenomegaly compared those Despite dramatic increase decrease splenic numbers noted while remained constant between days 3 5 dramatically at day 7 These data suggest exhibit divergent myelopoietic It appears paradoxical failure contribute observed mortality.