Caspase Activation: Revisiting the Induced Proximity Model
作者： Yigong Shi
DOI: 10.1016/J.CELL.2004.06.007
关键词: Enzyme activator 、 Biochemistry 、 Effector 、 Caspase 、 Apoptosis 、 Cell biology 、 Cleavage (embryo) 、 Active site 、 Biology 、 Binding site 、 Programmed cell death
摘要: Caspases execute cell death. The mechanism of effector caspase activation primarily involves reorganization active site loops following the cleavage. Induced Proximity hypothesis, originally proposed to explain initiator caspases, has recently been reinterpreted be proximity-driven dimerization and consequently their activation. evidence supporting these models is critically evaluated other possible mechanisms for are discussed.
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