Caspases: Enemies Within

作者: N. A. Thornberry

DOI: 10.1126/SCIENCE.281.5381.1312

关键词:

摘要: Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component this machinery is a proteolytic system involving family proteases called caspases. These enzymes participate in cascade that triggered response to proapoptotic signals and culminates cleavage set proteins, resulting disassembly the cell. Understanding caspase regulation intimately linked ability rationally manipulate apoptosis for therapeutic gain.

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