The energy balance positively regulates the levels of circulating TNF-related apoptosis inducing ligand in humans

摘要: Summary Background & aims Although decreased levels of circulating TRAIL have been associated to cardiovascular risk and overall mortality, the mechanisms controlling in physiopathological conditions are currently unknown. The aim present study was investigate whether changes energy intake insulin sensitivity may influence TRAIL, analyze potential relationships between fat mass healthy subjects receiving hypocaloric or hypercaloric diets. Methods Three distinct groups participants were studied, at end a 14-day ( n  = 9), 35-day  = 30) 60-day  = 16) period experimental bed rest induce resistance during controlled ambulation, after eucaloric, Results After conditions, restriction significantly while overfeeding increased with respect eucaloric control subjects. Moreover, positive correlation found as well balance, determined by these Conclusions Circulating exhibit clear-cut balance physical inactivity.