TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors
作者： Verena Zoller , Jan-Bernd Funcke , Michaela Keuper , Muad Abd El Hay , Klaus-Michael Debatin
关键词: Transcription factor 、 Caspase 、 Adipocyte 、 Cell biology 、 Adipogenesis 、 Adipose tissue 、 Chemistry 、 Downregulation and upregulation 、 Tumor necrosis factor alpha 、 White adipose tissue
摘要: Tumor necrosis factor-α (TNFα) and other ligands of the TNF superfamily are potent regulators adipose tissue metabolism play a crucial role in obesity-induced inflammation tissue. Adipose expression levels TRAIL (TNF-related apoptosis-inducing ligand) its receptor were shown to be upregulated by overfeeding decreased fasting mice. In present study we aimed elucidate impact on adipogenesis. To this end, human Simpson-Golabi-Behmel syndrome (SGBS) preadipocytes as well stromal-vascular cells isolated from white used model systems. Human recombinant inhibited adipogenic differentiation dose-dependent manner. It activated cleavage caspase-8 -3, which turn resulted downregulation key transcription factors C/EBPα, C/EBPδ, PPARγ. The effect was completely blocked pharmacological or genetic inhibition caspases. Taken together discovered so far unrecognized function regulation Targeting TRAIL/TRAIL system might provide novel strategy interfere with homeostasis.
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sci-hub.se 参考文章(53)
M R Rippo, L Babini, F Prattichizzo, L Graciotti, G Fulgenzi, F Tomassoni Ardori, F Olivieri, G Borghetti, S Cinti, A Poloni, F Fazioli, A D Procopio, Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes Cell Death and Disease. ,vol. 4, ,(2013) , 10.1038/CDDIS.2013.115
Erika Rimondi, Paola Secchiero, Andrea Quaroni, Carlotta Zerbinati, Silvano Capitani, Giorgio Zauli, Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation. Journal of Cellular Physiology. ,vol. 206, pp. 647- 654 ,(2006) , 10.1002/JCP.20512
Eugene Varfolomeev, Heather Maecker, Darcie Sharp, David Lawrence, Mark Renz, Domagoj Vucic, Avi Ashkenazi, Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. Journal of Biological Chemistry. ,vol. 280, pp. 40599- 40608 ,(2005) , 10.1074/JBC.M509560200
W P Cawthorn, F Heyd, K Hegyi, J K Sethi, Tumour necrosis factor- α inhibits adipogenesis via a β -catenin/TCF4(TCF7L2)-dependent pathway Cell Death & Differentiation. ,vol. 14, pp. 1361- 1373 ,(2007) , 10.1038/SJ.CDD.4402127
Leila Idrissova, Harmeet Malhi, Nathan W. Werneburg, Nathan K. LeBrasseur, Steven F. Bronk, Christian Fingas, Tamar Tchkonia, Tamar Pirtskhalava, Thomas A. White, Michael B. Stout, Petra Hirsova, Anuradha Krishnan, Christian Liedtke, Christian Trautwein, Niklas Finnberg, Wafik S. El-Deiry, James L. Kirkland, Gregory J. Gores, Trail Receptor Deletion in Mice Suppresses the Inflammation of Nutrient Excess Journal of Hepatology. ,vol. 62, pp. 1156- 1163 ,(2015) , 10.1016/J.JHEP.2014.11.033
Shinji Kamada, Ushio Kikkawa, Yoshihide Tsujimoto, Tony Hunter, Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). Journal of Biological Chemistry. ,vol. 280, pp. 857- 860 ,(2005) , 10.1074/JBC.C400538200
Evan D. Rosen, Bruce M. Spiegelman, What We Talk About When We Talk About Fat Cell. ,vol. 156, pp. 20- 44 ,(2014) , 10.1016/J.CELL.2013.12.012
Giorgio Zauli, Erika Rimondi, Vanessa Nicolin, Elisabetta Melloni, Claudio Celeghini, Paola Secchiero, TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF Blood. ,vol. 104, pp. 2044- 2050 ,(2004) , 10.1182/BLOOD-2004-03-1196
S Shalini, L Dorstyn, S Dawar, S Kumar, Old, new and emerging functions of caspases. Cell Death & Differentiation. ,vol. 22, pp. 526- 539 ,(2015) , 10.1038/CDD.2014.216
Jeffrey Chan, Leonel Prado-Lourenco, Levon M. Khachigian, Martin R. Bennett, Belinda A. Di Bartolo, Mary M. Kavurma, TRAIL Promotes VSMC Proliferation and Neointima Formation in a FGF-2–, Sp1 Phosphorylation–, and NFκB-Dependent Manner Circulation Research. ,vol. 106, pp. 1061- 1071 ,(2010) , 10.1161/CIRCRESAHA.109.206029