Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 in porcine circovirus 2-induced granulomatous inflammation.
作者： J. Kim , C. Chae
DOI: 10.1016/J.JCPA.2004.02.001
关键词: Macrophage 、 Monocyte 、 Cell 、 Lymph 、 Porcine circovirus 、 Macrophage inflammatory protein 、 Pathology 、 Chemotaxis 、 In vivo 、 Biology 、 Immunology
摘要: The expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory (MIP-1) in granulomatous inflammation lymph nodes was determined 1-day-old piglets inoculated intranasally with porcine circovirus 2 (PCV2). methods used were reverse transcription-polymerase chain reaction (RT-PCR), lesion scoring, in-situ hybridization. Maximum MCP-1 MIP-1 observed at 17 21 days post-inoculation (dpi), respectively. Granulomatous lesions maximum severity somewhat later (28 dpi). A close cell to relation between PCV2 the two cytokines serial sections from suggested that their induction a direct response PCV2. results provide evidence ability induce vivo.
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