Immune responses and vaccine-induced immunity against Porcine circovirus type 2
作者： T. Kekarainen , K. McCullough , M. Fort , C. Fossum , J. Segalés
DOI: 10.1016/J.VETIMM.2010.03.025
关键词:
摘要: Porcine circovirus type 2 (PCV2) is essential but not sufficient for postweaning multisystemic wasting syndrome (PMWS) occurrence in pigs. The outcome of PCV2 infection depends on the specific immune responses that are developing during infection. Diseased pigs immunosupressed and unable to mount effective clear virus from circulation. In final stage, PMWS-affected suffer extensive lymphoid lesions altered cytokine expression patterns peripheral blood mononuclear cells (PBMCs) organs. can also be asymptomatic, demonstrating every will guarantee severe immunopathological disturbances. Asymptomatic animals have higher neutralising antibody titres than animals. Recent results pointed out mechanisms by which affect involve induction IL-10, accumulation into modulation plasmacytoid dendritic role viral DNA regulation cell functions. Fourteen years after first description PMWS Canada, efficient commercial vaccines against available. vaccine success based activated humoral cellular PCV2. This review focuses recent research immunological aspects infections summarizes what currently known about vaccine-induced immunity.
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