Consequences of the Convergence of Multiple Alternate Pathways on the Estrogen Receptor in the Treatment of Metastatic Breast Cancer

摘要: Endocrine therapy is the usual first-line for patients with hormone receptor-positive metastatic breast cancer. However, resistance to therapies frequently occurs during course of treatment. Growing understanding signal cascade estrogen receptors and signaling pathways that interact has revealed complex role these in cell growth proliferation, on mechanism development resistance. These insights have led targeted may prove be effective options treatment cancer overcome This article reviews current cellular receptor receptors. It also data from recent ongoing clinical trials examine effects therapies, which might interfere reduce or reverse traditional, sequential, single-agent endocrine therapy.