Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease.
作者： Heidi N. Hilton , Tram B. Doan , J. Dinny Graham , Samantha R. Oakes , Audrey Silvestri
关键词:
摘要: Cumulative exposure to estrogen (E) and progesterone (P) over the menstrual cycle significantly influences risk of developing breast cancer. Despite dogma that PR in merely serves as a marker an active receptor (ER), inhibitor proliferative actions E, it is now clear P increases proliferation independently E action. We show here (PR) ER are expressed different epithelial populations, target non-overlapping pathways normal human breast. In cancer, becomes highly correlated with ER, this convergence associated signaling predictive disease metastasis. These data challenge established paradigm function co-operatively breast, have significant implications not only for our understanding biology, but also diagnosis, prognosis and/or treatment options cancer patients.
uq.edu.au参考文章(60)
Sue A. Bartow, Use of the autopsy to study ontogeny and expression of the estrogen receptor gene in human breast. Journal of Mammary Gland Biology and Neoplasia. ,vol. 3, pp. 37- 48 ,(1998) , 10.1023/A:1026641401184
Elizabeth Anderson, Robert B. Clarke, Anthony Howell, Estrogen responsiveness and control of normal human breast proliferation. Journal of Mammary Gland Biology and Neoplasia. ,vol. 3, pp. 23- 35 ,(1998) , 10.1023/A:1018718117113
N. S. B. Rawson, L. Turnbull, C. Nolan, D. Ricketts, R. Bakhshi, G. Ryall, J.-C. Gazet, R. C. Coombes, Estrogen and progesterone receptors in the normal female breast. Cancer Research. ,vol. 51, pp. 1817- 1822 ,(1991)
E Sim, A Abuhammad, A Ryan, Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. British Journal of Pharmacology. ,vol. 171, pp. 2705- 2725 ,(2014) , 10.1111/BPH.12598
Sylvia C. Hewitt, Joshua C. Harrell, Kenneth S. Korach, LESSONS IN ESTROGEN BIOLOGY FROM KNOCKOUT AND TRANSGENIC ANIMALS Annual Review of Physiology. ,vol. 67, pp. 285- 308 ,(2005) , 10.1146/ANNUREV.PHYSIOL.67.040403.115914
Elodie Bachelard-Cascales, Marion Chapellier, Emmanuel Delay, Gaetan Pochon, Thibault Voeltzel, Alain Puisieux, Claude Caron de Fromentel, Véronique Maguer-Satta, The CD10 enzyme is a key player to identify and regulate human mammary stem cells. Stem Cells. ,vol. 28, pp. 1081- 1088 ,(2010) , 10.1002/STEM.435
Fouad I. Boulos, William D. Dupont, Jean F. Simpson, Peggy A. Schuyler, Melinda E. Sanders, Marcia E. Freudenthal, David L. Page, Histologic associations and long-term cancer risk in columnar cell lesions of the breast Cancer. ,vol. 113, pp. 2415- 2421 ,(2008) , 10.1002/CNCR.23873
Heidi N. Hilton, N. Santucci, A. Silvestri, S. Kantimm, L. I. Huschtscha, J. D. Graham, C. L. Clarke, Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment. ,vol. 143, pp. 423- 433 ,(2014) , 10.1007/S10549-013-2817-2
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group Co-chairs Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 c, Writing committee Curtis† Christina 15 16 Shah Sohrab P. 17 18 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 e, Steering committee Brenton James D. 15 16 Ellis Ian 19 Huntsman David 17 18 Pinder Sarah 20 Purushotham Arnie 20 Murphy Leigh 21 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 j, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Chia Steven 18 Gelmon Karen 18 Huntsman David 17 18 McKinney Steven 17 18 Speers Caroline 18 Turashvili Gulisa 17 18 Watson Peter 17 18 21, University of Nottingham Ellis Ian 19 Blamey Roger 19 Green Andrew 19 Macmillan Douglas 19 Rakha Emad 19, King’s College London Purushotham Arnie 20 Gillett Cheryl 20 Grigoriadis Anita 20 Pinder Sarah 20 de Rinaldis Emanuele 20 Tutt Andy 20, Manitoba Institute of Cell Biology Murphy Leigh 21 Parisien Michelle 21 Troup Sandra 21, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Turashvili Gulisa 17 18 Bell Lynda 18 Chow Katie 18 Gale Nadia 18 Huntsman David 17 18 Kovalik Maria 18 Ng Ying 18 Prentice Leah 18, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Shah Sohrab P. 17 18 Bashashati Ali 17 Ha Gavin 17 Haffari Gholamreza 17 McKinney Steven 17 18, None, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature. ,vol. 486, pp. 346- 352 ,(2012) , 10.1038/NATURE10983
Kathryn B. Horwitz, Carol A. Sartorius, Progestins in Hormone Replacement Therapies Reactivate Cancer Stem Cells in Women with Preexisting Breast Cancers: A Hypothesis The Journal of Clinical Endocrinology and Metabolism. ,vol. 93, pp. 3295- 3298 ,(2008) , 10.1210/JC.2008-0938