The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
作者： Christina Curtis , Sohrab P Shah , Suet-Feung Chin , Gulisa Turashvili , Oscar M Rueda
DOI: 10.1038/NATURE10983
关键词:
摘要: The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expression in∼ …
nature.com
core.ac.uk
scienceopen.com
utsystem.edu参考文章(30)
John M. Kyriakis, Srikanth Jammulapati, Sean V. Tavtigian, Michelle Baumgard, Paul Bartel, Joseph Avruch, Arnold Oliphant, David Frank, Alexander K C Wong, Mark H. Skolnick, Thaylon Davis, Brad Swedlund, Teresa Janecki, William L. Perry, Ralph Pero, Cheryl Frye, David H F Teng, Alun Thomas, Rong Hu, Marianne Schroeder, Russell Bell, Amber Leavitt, Jeffrey T. Mitchell, David Sexton, Thomas Hattier, Pi Hsia Su, Simin Berry, James K. Hogan, Human Mitogen-activated Protein Kinase Kinase 4 as a Candidate Tumor Suppressor Cancer Research. ,vol. 57, pp. 4177- 4182 ,(1997)
Paula Diegelman, Scott A. Christopher, Carl W. Porter, Warren D. Kruger, Methylthioadenosine Phosphorylase, a Gene Frequently Codeleted with p16cdkN2a/ARF, Acts as a Tumor Suppressor in a Breast Cancer Cell Line Cancer Research. ,vol. 62, pp. 6639- 6644 ,(2002)
Siân Jones, Tian-Li Wang, Ie-Ming Shih, Tsui-Lien Mao, Kentaro Nakayama, Richard Roden, Ruth Glas, Dennis Slamon, Luis A. Diaz, Bert Vogelstein, Kenneth W. Kinzler, Victor E. Velculescu, Nickolas Papadopoulos, Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma Science. ,vol. 330, pp. 228- 231 ,(2010) , 10.1126/SCIENCE.1196333
J. C. Lin, J. Cummins, S. Boca, L. D. Wood, D. W. Parsons, S. Jones, T. Sjoblom, B.-H. Park, R. Parsons, J. Willis, D. Dawson, J. K. V. Willson, T. Nikolskaya, Y. Nikolsky, L. Kopelovich, N. Papadopoulos, L. A. Pennacchio, T.-L. Wang, S. D. Markowitz, G. Parmigiani, K. W. Kinzler, B. Vogelstein, V. E. Velculescu, R. J. Leary, Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 16224- 16229 ,(2008) , 10.1073/PNAS.0808041105
Thomas Santarius, Janet Shipley, Daniel Brewer, Michael R. Stratton, Colin S. Cooper, A census of amplified and overexpressed human cancer genes Nature Reviews Cancer. ,vol. 10, pp. 59- 64 ,(2010) , 10.1038/NRC2771
Lindsay A. Brown, Steve E. Kalloger, Melinda A. Miller, Ie-Ming Shih, Steven E. McKinney, Jennifer L. Santos, Ken Swenerton, Paul T. Spellman, Joe Gray, C. Blake Gilks, David G. Huntsman, Amplification of 11q13 in ovarian carcinoma. Genes, Chromosomes and Cancer. ,vol. 47, pp. 481- 489 ,(2008) , 10.1002/GCC.20549
Jing Tan, Puay Leng Lee, Zhimei Li, Xia Jiang, Yaw Chyn Lim, Shing Chuan Hooi, Qiang Yu, B55β-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer Cancer Cell. ,vol. 18, pp. 459- 471 ,(2010) , 10.1016/J.CCR.2010.10.021
Graham R. Bignell, Chris D. Greenman, Helen Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathon Hinton, Ciara Fahey, Beiyuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin T. Teh, Panos Deloukas, Fengtang Yang, Peter J. Campbell, P. Andrew Futreal, Michael R. Stratton, Signatures of mutation and selection in the cancer genome Nature. ,vol. 463, pp. 893- 898 ,(2010) , 10.1038/NATURE08768
Koei Chin, Sandy DeVries, Jane Fridlyand, Paul T. Spellman, Ritu Roydasgupta, Wen-Lin Kuo, Anna Lapuk, Richard M. Neve, Zuwei Qian, Tom Ryder, Fanqing Chen, Heidi Feiler, Taku Tokuyasu, Chris Kingsley, Shanaz Dairkee, Zhenhang Meng, Karen Chew, Daniel Pinkel, Ajay Jain, Britt Marie Ljung, Laura Esserman, Donna G. Albertson, Frederic M. Waldman, Joe W. Gray, Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. ,vol. 10, pp. 529- 541 ,(2006) , 10.1016/J.CCR.2006.10.009
Marjanka K Schmidt, Flora E van Leeuwen, Jelle Wesseling, Maggie CU Cheang, Karen Gelmon, Torsten O Nielsen, Carl Blomqvist, Päivi Heikkilä, Tuomas Heikkinen, Annegien Broeks, Heli Nevanlinna, Lars A Akslen, Louis R Bégin, William D Foulkes, Fergus J Couch, Xianshu Wang, Vicky Cafourek, Janet E Olson, Laura Baglietto, Graham G Giles, Gianluca Severi, Catriona A McLean, Melissa C Southey, Emad Rakha, Andrew R Green, Ian O Ellis, Mark E Sherman, Jolanta Lissowska, William F Anderson, Angela Cox, Simon S Cross, Malcolm WR Reed, Elena Provenzano, Sarah-Jane Dawson, Alison M Dunning, Manjeet Humphreys, Douglas F Easton, Montserrat García-Closas, Carlos Caldas, Paul D Pharoah, David G Huntsman, Fiona M Blows, Kristy E Driver, None, Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies PLoS Medicine. ,vol. 7, pp. e1000279- 12 ,(2010) , 10.1371/JOURNAL.PMED.1000279