Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

摘要: We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions amplifications. found the genes altered by major changes, deletion all copies or amplification to at least 12 per cell, averaged 17 tumor. integrated these data with previous mutation analyses Reference Sequence same tumor types identified cellular pathways affected both point alterations. Pathways enriched for genetic alterations included those controlling cell adhesion, intracellular signaling, DNA topological change, cycle control. These provide an view sequencing on scale identify could prove useful cancer diagnosis therapy.