Topoisomerase II{alpha} Gene Amplification Predicts Favorable Treatment Response to Tailored and Dose-Escalated Anthracycline-Based Adjuvant Chemotherapy in HER-2/neu-Amplified Breast Cancer: Scandinavian Breast Group Trial 9401.
作者： Minna Tanner , Jorma Isola , Tom Wiklund , Björn Erikstein , Pirkko Kellokumpu-Lehtinen
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摘要: Purpose Amplification of the HER-2/neu and topoisomerase IIα (TOP2A) genes has been linked to effects anthracyclines. Their role in predicting outcome anthracycline-based adjuvant chemotherapy for breast cancer patients remained controversial. Patients Methods The present substudy Scandinavian Breast Group trial 9401, which an epirubicin-based regimen (nine courses tailored dose-escalated fluorouracil, epirubicin, cyclophosphamide [FEC]) was compared with three or four standard FEC followed by bone marrow–supported high-dose (cyclophosphamide, thiotepa, carboplatin), included high-risk (with eight more positive axillary lymph nodes at least five additional poor prognostic indicators). determined retrospectively paraffin-embedded tumor tissue sections chromogenic situ hybridization. TOP2A tested only HER-2/neu–amplified tumors. Results ampli...
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