摘要: Individual variation in response to a therapy for the same type of cancer is well known; some patients show no response, whereas others dramatic response. It obvious that concept “one medicine all with disease” does not hold and more individualized approach needed. Although individualization certain treatments has been carried out pregenomic era, personalized as described this chapter follows progress study human diseases at molecular level, advances diagnostics, drug development based on various omics such genomics, proteomics, metabolomics biomarkers. The aim match right patient. broad scope includes predisposition testing, determination prognosis, combination diagnostics therapeutics, monitoring therapy.
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Maria J. Worsham, Haythem Ali, Jadranka Dragovic, Vanessa P. Schweitzer, Molecular Characterization of Head and Neck Cancer Molecular Diagnosis & Therapy. ,vol. 16, pp. 209- 222 ,(2012) , 10.1007/BF03262210
Alexander Röth, Calvin B. Harley, Gabriela M. Baerlocher, Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy Recent results in cancer research. ,vol. 184, pp. 221- 234 ,(2010) , 10.1007/978-3-642-01222-8_16
Christine L.H. Snozek, Dennis J. O'Kane, Alicia Algeciras-Schimnich, Pharmacogenetics of Solid Tumors: Directed Therapy in Breast, Lung, and Colorectal Cancer The Journal of Molecular Diagnostics. ,vol. 11, pp. 381- 389 ,(2009) , 10.2353/JMOLDX.2009.090003
Kewal K Jain, KK Jain, None, Textbook of personalized medicine Springer New York. ,(2009) , 10.1007/978-1-4419-0769-1
Pierre Chaurand, Melinda E. Sanders, Roy A. Jensen, Richard M. Caprioli, Proteomics in Diagnostic Pathology : Profiling and Imaging Proteins Directly in Tissue Sections American Journal of Pathology. ,vol. 165, pp. 1057- 1068 ,(2004) , 10.1016/S0002-9440(10)63367-6
Zhen Su, Jens Dannull, Benjamin K. Yang, Philipp Dahm, Doris Coleman, Donna Yancey, Sylvia Sichi, Donna Niedzwiecki, David Boczkowski, Eli Gilboa, Johannes Vieweg, Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. Journal of Immunology. ,vol. 174, pp. 3798- 3807 ,(2005) , 10.4049/JIMMUNOL.174.6.3798
James Suen, Vaneerat Ratanatharathorn, Ehab Hanna, Randy Breau, Dennis C. Shrieve, Xueqing Xia, Shulin Li, A Novel Alternative Approach for Prediction of Radiation Response of Squamous Cell Carcinoma of Head and Neck Cancer Research. ,vol. 61, pp. 2376- 2380 ,(2001)
, The Global Cancer Genomics Consortium: Interfacing Genomics and Cancer Medicine Cancer Research. ,vol. 72, pp. 3720- 3724 ,(2012) , 10.1158/0008-5472.CAN-12-1054
Lorenzo Pilla, Licia Rivoltini, Roberto Patuzzo, Andrea Marrari, Riccardo Valdagni, G Parmiani, Multipeptide vaccination in cancer patients Expert Opinion on Biological Therapy. ,vol. 9, pp. 1043- 1055 ,(2009) , 10.1517/14712590903085109
M. L. Sos, S. Fischer, R. Ullrich, M. Peifer, J. M. Heuckmann, M. Koker, S. Heynck, I. Stuckrath, J. Weiss, F. Fischer, K. Michel, A. Goel, L. Regales, K. A. Politi, S. Perera, M. Getlik, L. C. Heukamp, S. Ansen, T. Zander, R. Beroukhim, H. Kashkar, K. M. Shokat, W. R. Sellers, D. Rauh, C. Orr, K. P. Hoeflich, L. Friedman, K.-K. Wong, W. Pao, R. K. Thomas, Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 18351- 18356 ,(2009) , 10.1073/PNAS.0907325106