The Global Cancer Genomics Consortium: Interfacing Genomics and Cancer Medicine

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DOI: 10.1158/0008-5472.CAN-12-1054

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摘要: The Global Cancer Genomics Consortium (GCGC) is an international collaborative platform that amalgamates cancer biologists, cutting edge genomics and high throughput expertise with medical oncologists surgical oncologists; they address the most important translational questions are central to research treatment. annual GCGC symposium was held at Advanced Centre for Treatment Research Education in Cancer, Mumbai, India on 9th 11th of November 2011. showcased next generation sequencing efforts explore specific transcriptomic changes, single nucleotide polymorphism, copy number variations various types cancers, as well structural approach develop new therapeutic targets chemical probes. From spectrum studies presented symposium, it evident translation emerging knowledge into clinical applications can only be achieved through integration multi-disciplinary expertise. In summary, provided practical approaches, exclusive focused endeavors

参考文章(20)
Meera Soundararajan, Jeyanthy Eswaran, Atypical GTPases as drug targets. Anti-cancer Agents in Medicinal Chemistry. ,vol. 12, pp. 19- 28 ,(2012) , 10.2174/187152012798764705
Masakazu Toi, Hiroyasu Yamashiro, Wakako Tsuji, Risk reduction of distant metastasis in hormone-sensitive postmenopausal breast cancer Breast Cancer. ,vol. 16, pp. 207- 218 ,(2009) , 10.1007/S12282-009-0096-X
Zhong Wang, Mark Gerstein, Michael Snyder, RNA-Seq: a revolutionary tool for transcriptomics Nature Reviews Genetics. ,vol. 10, pp. 57- 63 ,(2009) , 10.1038/NRG2484
Jeyanthy Eswaran, Dinesh Cyanam, Prakriti Mudvari, Sirigiri Divijendra Natha Reddy, Suresh B. Pakala, Sujit S. Nair, Liliana Florea, Suzanne A. W. Fuqua, Sucheta Godbole, Rakesh Kumar, Transcriptomic landscape of breast cancers through mRNA sequencing Scientific Reports. ,vol. 2, pp. 264- 264 ,(2012) , 10.1038/SREP00264
M. R. Stratton, Exploring the Genomes of Cancer Cells: Progress and Promise Science. ,vol. 331, pp. 1553- 1558 ,(2011) , 10.1126/SCIENCE.1204040
Manuel Rodríguez-Paredes, Manel Esteller, Cancer epigenetics reaches mainstream oncology Nature Medicine. ,vol. 17, pp. 330- 339 ,(2011) , 10.1038/NM.2305
Douglas Hanahan, Robert A Weinberg, The hallmarks of cancer. Cell. ,vol. 100, pp. 57- 70 ,(2000) , 10.1016/S0092-8674(00)81683-9
Ildiko Felletar, Martin Philpott, Shonagh Munro, Michael R. McKeown, Yuchuan Wang, Amanda L. Christie, Nathan West, Michael J. Cameron, Brian Schwartz, Tom D. Heightman, Nicholas La Thangue, Christopher A. French, Olaf Wiest, Andrew L. Kung, Stefan Knapp, James E. Bradner, Panagis Filippakopoulos, Jun Qi, Sarah Picaud, Yao Shen, William B. Smith, Oleg Fedorov, Elizabeth M. Morse, Tracey Keates, Tyler T. Hickman, Selective inhibition of BET bromodomains Nature. ,vol. 468, pp. 1067- 1073 ,(2010) , 10.1038/NATURE09504
Stephen B. Baylin, Peter A. Jones, A decade of exploring the cancer epigenome — biological and translational implications Nature Reviews Cancer. ,vol. 11, pp. 726- 734 ,(2011) , 10.1038/NRC3130
Paul Medvedev, Monica Stanciu, Michael Brudno, Computational methods for discovering structural variation with next-generation sequencing Nature Methods. ,vol. 6, ,(2009) , 10.1038/NMETH.1374